Determination of multi-class drugs in meat by liquid chromatography-mass spectrometry

R.VÃƒÂƒÃ‚ÂƒÃƒÂ‚Ã‚Â­ctor HormazÃƒÂƒÃ‚ÂƒÃƒÂ‚Ã‚Â¡bal; ÃƒÂƒÃ‚ÂƒÃƒÂ‚Ã‚Â˜yvin ÃƒÂƒÃ‚ÂƒÃƒÂ‚Ã‚Â˜stensvik

Analytical Chemistry: An Indian Journal
ISSN (PRINT): 0974-7419

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Abstract

Determination of multi-class drugs in meat by liquid chromatography-mass spectrometry

Author(s): R.V�?�?�?�?�?�?�?ctor Hormaz�?�?�?�?�?�?�?¡bal, �?�?�?�?�?�?�?�?yvin �?�?�?�?�?�?�?�?stensvik

A simple liquid chromatographic-mass spectrometry (LC-MS/MS) method for the determination of different veterinary drugs, i.e. ß-lactams, quinolones, sulfonamides, tetracyclines, nitromidazoles, meloxicams and corticosteroids in meat is described. The sample was homogenized with extraction solution and centrifuged. The supernatant were left in the freezer (-20 °C) for 30 minutes and centrifuged. Thereafter 2.75 ml supernatant was evaporated to 0.4 mL. The sample was mixed, filtered, diluted and injected into the LC-MS/MS.