Abstract

Comparison of Sonochemical and Conventional Methodologies for the Efficient Multicomponent one-pot Synthesis of Tetra-Substituted Imidazoles

Author(s): Aeysha Sultan1*, Roberto Acevedo 2

Sonochemical reactions are one of the most explored synthetic methodologies in the current era. The combination of green approach, efficiency and selectivity of sonochemical synthesis makes it a quite worth exploring filed. Imidazoles are interesting heterocyclic compounds that are integral part of a number structural scaffolds of medicinal, synthetic and industrial importance. The presented work is centered around comparison of different conventional and nonconventional synthetic strategies, including sonochemistry, for the synthesis of tetrasubstituted imidazoles using facilie method(s) that would afford product in high yields. The work involved multicomponent reaction between aromatic aldehydes, aniline, benzil and ammonium acetate in presence of Lewis acid catalysts. Best yields were obtained when FeCl3 was used as catalyst whereby 87% yield of product was obtained at 30C with in 30 min of reaction time.