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Abstract

Comparative in vitro Evaluation of Commercial Montelukast Sodium Chewable Tablets

Author(s): N. K. D. Devi, A. P. Rani, B. R. Madhavi, B. S. Mrudula, K. Sujitha and M. Janaki

Montelukast sodium chewable tablets (5 mg) were evaluated for in vitro parameters, both official and non-official, viz., uniformity of weight, hardness test, tensile strength, friability test, in vitro dissolution test and assay. All the products were within the general specifications as per IP and USP for tablet formulation. The study on the dissolution profile revealed that product ‘C’ had faster dissolution rate while compared to products ‘A’ and ‘B’. Assay values were within the limits of 95 % to 105 %. The data obtained through these studies may be useful for further formulation development studies


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