Abstract

Antiulcer Activity of Ammania Baccifera Linn

Author(s): B. Madulatha, G. Narayana Murthy, Kotresh Yaligar and I. J. Kuppast

The petroleum ether, methanol, chloroform and aqueous fractions of the ethanolic extract of Ammania baccifera Linn whole plant were evaluated for their antiulcer potential at a dose of 400 mg/kg b.w. p.o. against pyloric ligation and indomethacin induced gastric ulcer models in Albino rats. Ranitidine was used as a reference standard for both the models. The antiulcer effect was assessed by parameters such as gastric volume, pH, free acidity, total acidity, ulcer index and percent inhibition. The methanolic fraction exhibited highly significant antiulcer effect against both pyloric ligation and indomethacin induced gastric ulcers in Albino rats. The phytochemical studies revealed the presence of alkaloids, carbohydrates, steroids, tannins, triterpenes, and flavanoids in the ethanolic extract; steroids in the pet. ether fraction; alkaloids, steroids, triterpenes and flavanoids in the methanolic fraction; alkaloids in the chloroform fraction; flavanoids in the aqueous fraction.