Abstract

Antibacterial activity, synthesis and characterisation of complexes ofCu II,NiII, ZnII, FeII,MnII, PdII andCdII with thiosemicarbazone of 2-acetylbenzimidazole {(2E)-2-[1-(1H-benzimidazole-2-yl) ethylidiene] hydrazinecarbothioamide}

Author(s): Debojyoti Chakraborty, Sita Ram Sharma, Madhu Bala, Khursheed Mohammad, Rakesh Roshan, Ranvir Kumar

Thiosemicarbazone of 2-acetylbenzimidazole (2E)-2-[1-(1H-benzimidazole- 2-yl) ethylidiene] hydrazinecarbothioamide (HActtsc) is strong (N, S) donor complexingmolecules and formchelates with CoII, NiII, FeII, CuII,MnII, ZnII, CdII and PdII of composition M (Acttsc)2. nH2O (n = 0, 1 or 2) in neutral or basic medium. In anhydrous ethanol or methanol CuII, NiII, ZnII, and CdII formdihalo complexes of composition [M(HActtsc)X2] (X = Cl or Br). The complexes have been analysed and characterised from the studies of electrical conductance value, magnetic susceptibility measurement, electronic absorption and infrared spectral data. The antibacterial activity of HActtsc and its complexes have been evaluated against some gram positive and gram negative bacteria by disc diffusion method.