All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

An Efficient One Pot Three Component Synthesis of 4-Aryl-6-(3-Coumarinyl) Pyrimidin-2 (1h)-Ones Under Solvent Free Conditions

Author(s): B. Prasanna, K. Praveen Kumar, N. Rakesh and Y. Prashanthi

Silica gel supported zirconyl chloride octahydrate was found to be an efficient and recyclable catalyst for the synthesis of a series of biologically important molecules in high turnover numbers and rates. Substituted 4-aryl-6-(3-coumarinyl) pyrimidin-2 (1H)-ones can be prepared in high yield and purity by direct reaction via., cyclocondensation of urea and 3-acetylcoumarin with substituted aldehydes in the presence of a catalytic amount of ZrOCl2.8H2O/SiO2 as Lewis acid and at ambient temperature under solvent-free conditions. The synthesized compounds 4(a-e) were characterized by IR, NMR and Mass spectral analysis.


Share this       
Google Scholar citation report
Citations : 9398

International Journal of Chemical Sciences received 9398 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

View More