Abstract
An efficient and facile synthesis of 2-bromo-5-methylpyrazine
Author(s): G.Madhusudhan, Raman Vysabhattar, R.Naveen Reddy, B.Venkata NarayanaA facile and efficient synthesis of 2-bromo-5-methyl pyrazine is described. The synthetic scheme involves the conversion of 5-methylpyrazine-2-carboxylic acid to the corresponding amide which on Hofmann degradation gives the amine compound. This amine compound on diazotization followed by in-situ bromination produces the targeted 2-bromo-5-methyl pyrazine.
