Abstract

Allium Sativum Prevents the Induced-Hepatotoxicity, Abnormal Blood Hemolysis and Viscosity in Rats

Author(s): Attalla Farag El-kott, Saad M amd Abdalla Mohamed Khalil

The present study was conducted to investigate the chemo preventive effects of garlic extract on carbon tetrachloride (CCl4)-induced hepato toxicity in male albino rats, were studied for its protective effects against hepato toxic, abnormal blood hemolysis and viscosity induced using carbon tetrachloride (CCl4) in rats. Male Wistar rats were administered CCl4 by intra peritoneal injection for 7 weeks and received a normal diet or normal diet with extracted garlic for the same period. Extracted garlic significantly reduced the liver damage, including fibrosis and fatty infiltration, vaculation, and sinusoid dilated in a dose dependent manner. Moreover, extracted garlic significantly decreased the elevation in plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin (P < 0.01). It also restored the decrease in blood hemolysis (P < 0.05) and viscosity (P < 0.01) during CCl4 treatment. These results suggested that extracted garlic may protect the liver against CCl4-induced fibrosis, abnormal blood hemolysis and viscosity. This protective effect appears due to garlic antioxidant properties.