Abstract
A simple and efficient synthesis of calciumchannel blocker Flunarizine
Author(s): A.Venkat Narsaiah, J.Kranthi KumarT-type calciumchannel blocker and anti-ischemic drug 1-[bis (4-fluorophenyl) methyl]-4-cinnamylpiperazine (1) synthesis has been carried out in four steps with an average of 70% yield. This route is very convenient and can be applied for large scale preparation of Flunarizine with high yields.
